Leptin/OB Antibody AF398 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemLeptin/OB Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAF398
NCBI Gene AliasesLEPD, OB, OBS
ApplicationsWestern Blot, Immunohistochemistry, Neutralization
ReactivityHuman
Conjugate/TagUnconjugated
HostGoat
Quantity100 ug (also 25 ug)
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
IsotypeIgG
TargetLeptin/OB
NCBI Full Gene Nameleptin
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant human Leptin/OB, Val22-Cys167, Accession # Q6NT58
ConcentrationLYOPH
PurityAntigen Affinity-purified
Brand/TrademarkR&D Systems, a Bio-Techne Brand
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects human Leptin/OB in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 25% cross-reactivity with recombinant mouse Leptin/OB is observed

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Reversion of breast epithelial polarity alterations caused by obesitynpj Breast CancerMay 9, 2023Julia Holmes, Mohamed Gaber, Mónica Z. Jenks, Adam Wilson, Tucker Loy, Cassandra Lepetit, Mara Z. Vitolins, Brittney-Shea Herbert, Katherine L. Cook, Pierre-Alexandre Vidirecombinant leptin (Protein Laboratories Rehovot), leptin-neutralizing antibodies (R&D Systems, cat# AF398; 150 µg/ml), recombinant human IGF-1 (PeproTech, cat# 100-11), human recombinant insulin (MilliporeSigma,

(2) Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2Science translational medicineFebruary 22, 2023Bhardwaj P, Iyengar NM, Zahid H, Carter KM, Byun DJ, Choi MH, Sun Q, Savenkov O, Louka C, Liu C, et al.studies, obese CM was preincubated with a leptin-neutralizing antibody (Lep Ab; 13.3 μg/ml; R&D Systems, #AF398, RRID:AB_355347) for 1 hour at 4°C, and then cells were treated with lower weight or obese CM alone

(3) Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesityPediatric DiabetesMarch 1, 2020Christine Frithioff‐Bøjsøe, Morten A.V. Lund, Ulrik Lausten‐Thomsen, Paula L. Hedley, Oluf Pedersen, Michael Christiansen, Jennifer L. Baker, Torben Hansen, Jens‐Christian Holmpurified Escherichia coli expressed recombinant human leptin provided by the manufacturer (Catalog no.: AF398, R&D Systems, Minneapolis, MN, USA). The intra- and inter-assay coefficients of variations were <5%

(4) UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skinScientific reportsMay 10, 2016Kim EJ, Kim YK, Kim MK, Kim S, Kim JY, Lee DH, Chung JH.

(5) Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical modelOncotargetNovember 30, 2015Mark Duquette et al.wells per each condition. Human Leptin blockage was performed using an antibody against Leptin (cat#AF398, R&D Systems, MN, USA). Quantitative multigene expression analysis mRNA The expression of EMC and

(6) Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer SpecimenPLOS ONEOctober 2, 2015Samar Basu, Kristell Combe, Fabrice Kwiatkowski, Florence Caldefie-Chézet, Frédérique Penault-Llorca, Yves-Jean Bignon, Marie-Paule VassonUppsala University, Uppsala, Sweden. The authorization number is C 298/96. Antibodies for leptin (1:40, AF398, R&D Systems, Lille, France), anti-Ob-R (1:40, AF389, R&D Systems, Lille, France), anti-AdipoR1 and

(7) Increased leptin expression in endometriosis cells is associated with endometrial stromal cell proliferation and leptin gene up-regulationMolecular human reproductionMay 1, 2002Wu MH, Chuang PC, Chen HM, Lin CC, Tsai SJ.

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Leptin/OB Antibody

Leptin/OB Antibody

Leptin/OB Antibody

Leptin/OB Antibody

Leptin/OB Antibody

Leptin/OB Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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Leptin/OB Antibody from R&D Systems, a Bio-Techne Brand

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